diff --git a/tests/test_settings/settings_5_0.py b/tests/test_settings/settings_5_0.py
new file mode 100644
index 00000000..c005b9ca
--- /dev/null
+++ b/tests/test_settings/settings_5_0.py
@@ -0,0 +1,124 @@
+"""
+Django settings for Anymail tests.
+
+Generated by 'django-admin startproject' using Django 5.0.6.
+
+For more information on this file, see
+https://docs.djangoproject.com/en/5.0/topics/settings/
+
+For the full list of settings and their values, see
+https://docs.djangoproject.com/en/5.0/ref/settings/
+"""
+
+from pathlib import Path
+
+# Build paths inside the project like this: BASE_DIR / 'subdir'.
+BASE_DIR = Path(__file__).resolve().parent.parent
+
+
+# Quick-start development settings - unsuitable for production
+# See https://docs.djangoproject.com/en/5.0/howto/deployment/checklist/
+
+# SECURITY WARNING: keep the secret key used in production secret!
+SECRET_KEY = "NOT_FOR_PRODUCTION_USE"
+
+# SECURITY WARNING: don't run with debug turned on in production!
+DEBUG = True
+
+ALLOWED_HOSTS = []
+
+
+# Application definition
+
+INSTALLED_APPS = [
+    "django.contrib.admin",
+    "django.contrib.auth",
+    "django.contrib.contenttypes",
+    "django.contrib.sessions",
+    "django.contrib.messages",
+    "django.contrib.staticfiles",
+    "anymail",
+]
+
+MIDDLEWARE = [
+    "django.middleware.security.SecurityMiddleware",
+    "django.contrib.sessions.middleware.SessionMiddleware",
+    "django.middleware.common.CommonMiddleware",
+    "django.middleware.csrf.CsrfViewMiddleware",
+    "django.contrib.auth.middleware.AuthenticationMiddleware",
+    "django.contrib.messages.middleware.MessageMiddleware",
+    "django.middleware.clickjacking.XFrameOptionsMiddleware",
+]
+
+ROOT_URLCONF = "tests.test_settings.urls"
+
+TEMPLATES = [
+    {
+        "BACKEND": "django.template.backends.django.DjangoTemplates",
+        "DIRS": [],
+        "APP_DIRS": True,
+        "OPTIONS": {
+            "context_processors": [
+                "django.template.context_processors.debug",
+                "django.template.context_processors.request",
+                "django.contrib.auth.context_processors.auth",
+                "django.contrib.messages.context_processors.messages",
+            ],
+        },
+    },
+]
+
+WSGI_APPLICATION = "tests.wsgi.application"
+
+
+# Database
+# https://docs.djangoproject.com/en/5.0/ref/settings/#databases
+
+DATABASES = {
+    "default": {
+        "ENGINE": "django.db.backends.sqlite3",
+        "NAME": BASE_DIR / "db.sqlite3",
+    }
+}
+
+
+# Password validation
+# https://docs.djangoproject.com/en/5.0/ref/settings/#auth-password-validators
+
+AUTH_PASSWORD_VALIDATORS = [
+    {
+        "NAME": "django.contrib.auth.password_validation.UserAttributeSimilarityValidator",
+    },
+    {
+        "NAME": "django.contrib.auth.password_validation.MinimumLengthValidator",
+    },
+    {
+        "NAME": "django.contrib.auth.password_validation.CommonPasswordValidator",
+    },
+    {
+        "NAME": "django.contrib.auth.password_validation.NumericPasswordValidator",
+    },
+]
+
+
+# Internationalization
+# https://docs.djangoproject.com/en/5.0/topics/i18n/
+
+LANGUAGE_CODE = "en-us"
+
+TIME_ZONE = "UTC"
+
+USE_I18N = True
+
+USE_TZ = True
+
+
+# Static files (CSS, JavaScript, Images)
+# https://docs.djangoproject.com/en/5.0/howto/static-files/
+
+STATIC_URL = "static/"
+
+# Default primary key field type
+# https://docs.djangoproject.com/en/5.0/ref/settings/#default-auto-field
+
+DEFAULT_AUTO_FIELD = "django.db.models.BigAutoField"
diff --git a/tox.ini b/tox.ini
index 1579487b..19aab224 100644
--- a/tox.ini
+++ b/tox.ini
@@ -25,8 +25,8 @@ envlist =
     django30-py{38,39,py38,py39}-all
     # ... then prereleases (if available) and current development:
     # Django 5.1 alpha: Python 3.10, 3.11, and 3.12
-    #django51-py{310,311,312}-all
-    # Django 5.1 dev: Python 3.10, 3.11, and 3.12
+    django51-py{310,311,312}-all
+    # Django 5.2 dev: Python 3.10, 3.11, and 3.12
     djangoDev-py{310,311,312}-all
     # ... then partial installation (limit extras):
     django50-py312-{none,amazon_ses,postal,resend}
@@ -45,7 +45,8 @@ deps =
     django40: django~=4.0.0
     django41: django~=4.1.0
     django42: django~=4.2.0
-    django50: django~=5.0.0a0
+    django50: django~=5.0.0
+    django51: django~=5.1.0a0
     djangoDev: https://github.com/django/django/tarball/main
 extras =
     # Install [esp-name] extras only when testing "all" or esp_name factor.