diff --git a/experimental/CHANGELOG.md b/experimental/CHANGELOG.md
index f2228b384f..b330cb043f 100644
--- a/experimental/CHANGELOG.md
+++ b/experimental/CHANGELOG.md
@@ -14,6 +14,7 @@ All notable changes to experimental packages in this project will be documented
 
 ### :bug: (Bug Fix)
 
+* fix(opentelemetry-instrumentation-http): use correct origin when port is `null` #2948 @danielgblanco
 * fix(otlp-exporter-base): include esm and esnext in package files #2952 @dyladan
 
 ### :books: (Refine Doc)
diff --git a/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts b/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts
index 68d7be7588..e1e98209db 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/src/utils.ts
@@ -263,9 +263,8 @@ export const getRequestInfo = (
     if (!pathname && optionsParsed.path) {
       pathname = url.parse(optionsParsed.path).pathname || '/';
     }
-    origin = `${optionsParsed.protocol || 'http:'}//${
-      optionsParsed.host || `${optionsParsed.hostname}:${optionsParsed.port}`
-    }`;
+    const hostname = optionsParsed.host || (optionsParsed.port != null ? `${optionsParsed.hostname}${optionsParsed.port}` : optionsParsed.hostname);
+    origin = `${optionsParsed.protocol || 'http:'}//${hostname}`;
   }
 
   const headers = optionsParsed.headers ?? {};
diff --git a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts
index 062f160bdc..52211abadc 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/utils.test.ts
@@ -72,11 +72,23 @@ describe('Utility', () => {
         ...urlParsed,
         pathname: undefined,
       };
+      const urlParsedWithUndefinedHostAndPort = {
+        ...urlParsed,
+        host: undefined,
+        port: undefined,
+      };
+      const urlParsedWithUndefinedHostAndNullPort = {
+        ...urlParsed,
+        host: undefined,
+        port: null,
+      };
       const whatWgUrl = new url.URL(webUrl);
       for (const param of [
         webUrl,
         urlParsed,
         urlParsedWithoutPathname,
+        urlParsedWithUndefinedHostAndPort,
+        urlParsedWithUndefinedHostAndNullPort,
         whatWgUrl,
       ]) {
         const result = utils.getRequestInfo(param);