diff --git a/.github/workflows/github-ci.yaml b/.github/workflows/github-ci.yaml
index 576c64e6f..734b8113b 100644
--- a/.github/workflows/github-ci.yaml
+++ b/.github/workflows/github-ci.yaml
@@ -22,7 +22,10 @@ jobs:
     strategy:
       matrix:
         python-version: ["3.6", "3.7", "3.8", "3.9", "3.10"]
-
+        use-cryptodome: [""]
+        include:
+          - python-version: "3.10"
+            use-cryptodome: "false"
     steps:
     - name: Checkout Code
       uses: actions/checkout@v3
@@ -38,6 +41,10 @@ jobs:
     - name: Install requirements (Python 3)
       run: |
         pip install -r requirements/ci.txt
+    - name: Remove cryptodome
+      run: |
+        pip uninstall pycryptodome -y
+      if: matrix.use-cryptodome == false
     - name: Install PyPDF2
       run: |
         pip install .
diff --git a/PyPDF2/_encryption.py b/PyPDF2/_encryption.py
index 621cc2d52..4327baf63 100644
--- a/PyPDF2/_encryption.py
+++ b/PyPDF2/_encryption.py
@@ -56,7 +56,7 @@ class CryptIdentity(CryptBase):
 
 
 try:
-    from Crypto.Cipher import AES, ARC4
+    from Crypto.Cipher import AES, ARC4  # type: ignore[import]
 
     class CryptRC4(CryptBase):
         def __init__(self, key: bytes) -> None:
diff --git a/tests/test_encryption.py b/tests/test_encryption.py
index c357fc237..43ebdf20e 100644
--- a/tests/test_encryption.py
+++ b/tests/test_encryption.py
@@ -3,6 +3,14 @@
 import pytest
 
 import PyPDF2
+from PyPDF2.errors import DependencyError
+
+try:
+    from Crypto.Cipher import AES  # noqa: F401
+
+    HAS_PYCRYPTODOME = True
+except ImportError:
+    HAS_PYCRYPTODOME = False
 
 TESTS_ROOT = os.path.abspath(os.path.dirname(__file__))
 PROJECT_ROOT = os.path.dirname(TESTS_ROOT)
@@ -10,46 +18,54 @@
 
 
 @pytest.mark.parametrize(
-    "name",
+    ("name", "requres_pycryptodome"),
     [
         # unencrypted pdf
-        "unencrypted.pdf",
+        ("unencrypted.pdf", False),
         # created by `qpdf --encrypt "" "" 40 -- unencrypted.pdf r2-empty-password.pdf`
-        "r2-empty-password.pdf",
+        ("r2-empty-password.pdf", False),
         # created by `qpdf --encrypt "" "" 128 -- unencrypted.pdf r3-empty-password.pdf`
-        "r3-empty-password.pdf",
+        ("r3-empty-password.pdf", False),
         # created by `qpdf --encrypt "asdfzxcv" "" 40 -- unencrypted.pdf r2-user-password.pdf`
-        "r2-user-password.pdf",
+        ("r2-user-password.pdf", False),
         # created by `qpdf --encrypt "asdfzxcv" "" 128 -- unencrypted.pdf r3-user-password.pdf`
-        "r3-user-password.pdf",
+        ("r3-user-password.pdf", False),
         # created by `qpdf --encrypt "asdfzxcv" "" 128 --force-V4 -- unencrypted.pdf r4-user-password.pdf`
-        "r4-user-password.pdf",
+        ("r4-user-password.pdf", False),
         # created by `qpdf --encrypt "asdfzxcv" "" 128 --use-aes=y -- unencrypted.pdf r4-aes-user-password.pdf`
-        "r4-aes-user-password.pdf",
+        ("r4-aes-user-password.pdf", True),
         # # created by `qpdf --encrypt "" "" 256 --force-R5 -- unencrypted.pdf r5-empty-password.pdf`
-        "r5-empty-password.pdf",
+        ("r5-empty-password.pdf", True),
         # # created by `qpdf --encrypt "asdfzxcv" "" 256 --force-R5 -- unencrypted.pdf r5-user-password.pdf`
-        "r5-user-password.pdf",
+        ("r5-user-password.pdf", True),
         # # created by `qpdf --encrypt "" "asdfzxcv" 256 --force-R5 -- unencrypted.pdf r5-owner-password.pdf`
-        "r5-owner-password.pdf",
+        ("r5-owner-password.pdf", True),
         # created by `qpdf --encrypt "" "" 256 -- unencrypted.pdf r6-empty-password.pdf`
-        "r6-empty-password.pdf",
+        ("r6-empty-password.pdf", True),
         # created by `qpdf --encrypt "asdfzxcv" "" 256 -- unencrypted.pdf r6-user-password.pdf`
-        "r6-user-password.pdf",
+        ("r6-user-password.pdf", True),
         # created by `qpdf --encrypt "" "asdfzxcv" 256 -- unencrypted.pdf r6-owner-password.pdf`
-        "r6-owner-password.pdf",
+        ("r6-owner-password.pdf", True),
     ],
 )
-def test_encryption(name):
+def test_encryption(name, requres_pycryptodome):
     inputfile = os.path.join(RESOURCE_ROOT, "encryption", name)
-    ipdf = PyPDF2.PdfReader(inputfile)
-    if inputfile.endswith("unencrypted.pdf"):
-        assert not ipdf.is_encrypted
+    if requres_pycryptodome and not HAS_PYCRYPTODOME:
+        with pytest.raises(DependencyError) as exc:
+            ipdf = PyPDF2.PdfReader(inputfile)
+            ipdf.decrypt("asdfzxcv")
+            dd = dict(ipdf.metadata)
+        assert exc.value.args[0] == "PyCryptodome is required for AES algorithm"
+        return
     else:
-        assert ipdf.is_encrypted
-        ipdf.decrypt("asdfzxcv")
-    assert len(ipdf.pages) == 1
-    dd = dict(ipdf.metadata)
+        ipdf = PyPDF2.PdfReader(inputfile)
+        if inputfile.endswith("unencrypted.pdf"):
+            assert not ipdf.is_encrypted
+        else:
+            assert ipdf.is_encrypted
+            ipdf.decrypt("asdfzxcv")
+        assert len(ipdf.pages) == 1
+        dd = dict(ipdf.metadata)
     # remove empty value entry
     dd = {x[0]: x[1] for x in dd.items() if x[1]}
     assert dd == {
@@ -69,6 +85,7 @@ def test_encryption(name):
         ("r6-both-passwords.pdf", "foo", "bar"),
     ],
 )
+@pytest.mark.skipif(not HAS_PYCRYPTODOME, reason="No pycryptodome")
 def test_both_password(name, user_passwd, owner_passwd):
     from PyPDF2 import PasswordType
 
@@ -80,6 +97,24 @@ def test_both_password(name, user_passwd, owner_passwd):
     assert len(ipdf.pages) == 1
 
 
+@pytest.mark.parametrize(
+    ("pdffile", "password"),
+    [
+        ("crazyones-encrypted-256.pdf", "password"),
+    ],
+)
+@pytest.mark.skipif(not HAS_PYCRYPTODOME, reason="No pycryptodome")
+def test_get_page_of_encrypted_file_new_algorithm(pdffile, password):
+    """
+    Check if we can read a page of an encrypted file.
+
+    This is a regression test for issue 327:
+    IndexError for get_page() of decrypted file
+    """
+    path = os.path.join(RESOURCE_ROOT, pdffile)
+    PyPDF2.PdfReader(path, password=password).pages[0]
+
+
 @pytest.mark.parametrize(
     "names",
     [
@@ -93,6 +128,7 @@ def test_both_password(name, user_passwd, owner_passwd):
         ),
     ],
 )
+@pytest.mark.skipif(not HAS_PYCRYPTODOME, reason="No pycryptodome")
 def test_encryption_merge(names):
     pdf_merger = PyPDF2.PdfMerger()
     files = [os.path.join(RESOURCE_ROOT, "encryption", x) for x in names]
diff --git a/tests/test_reader.py b/tests/test_reader.py
index 49ec3e79f..6018a196c 100644
--- a/tests/test_reader.py
+++ b/tests/test_reader.py
@@ -280,23 +280,6 @@ def test_get_page_of_encrypted_file(pdffile, password, should_fail):
         PdfReader(path, password=password).pages[0]
 
 
-@pytest.mark.parametrize(
-    ("pdffile", "password"),
-    [
-        ("crazyones-encrypted-256.pdf", "password"),
-    ],
-)
-def test_get_page_of_encrypted_file_new_algorithm(pdffile, password):
-    """
-    Check if we can read a page of an encrypted file.
-
-    This is a regression test for issue 327:
-    IndexError for get_page() of decrypted file
-    """
-    path = os.path.join(RESOURCE_ROOT, pdffile)
-    PdfReader(path, password=password).pages[0]
-
-
 @pytest.mark.parametrize(
     ("src", "expected", "expected_get_fields"),
     [