diff --git a/news/12175.removal.rst b/news/12175.removal.rst
new file mode 100644
index 00000000000..bf3500f351a
--- /dev/null
+++ b/news/12175.removal.rst
@@ -0,0 +1 @@
+Drop a fallback to using SecureTransport on macOS. It was useful when pip detected OpenSSL older than 1.0.1, but the current pip does not support any Python version supporting such old OpenSSL versions.
diff --git a/src/pip/_internal/__init__.py b/src/pip/_internal/__init__.py
index 6afb5c627ce..96c6b88c112 100755
--- a/src/pip/_internal/__init__.py
+++ b/src/pip/_internal/__init__.py
@@ -1,6 +1,5 @@
 from typing import List, Optional
 
-import pip._internal.utils.inject_securetransport  # noqa
 from pip._internal.utils import _log
 
 # init_logging() must be called before any call to logging.getLogger()
diff --git a/src/pip/_internal/utils/inject_securetransport.py b/src/pip/_internal/utils/inject_securetransport.py
deleted file mode 100644
index 276aa79bb81..00000000000
--- a/src/pip/_internal/utils/inject_securetransport.py
+++ /dev/null
@@ -1,35 +0,0 @@
-"""A helper module that injects SecureTransport, on import.
-
-The import should be done as early as possible, to ensure all requests and
-sessions (or whatever) are created after injecting SecureTransport.
-
-Note that we only do the injection on macOS, when the linked OpenSSL is too
-old to handle TLSv1.2.
-"""
-
-import sys
-
-
-def inject_securetransport() -> None:
-    # Only relevant on macOS
-    if sys.platform != "darwin":
-        return
-
-    try:
-        import ssl
-    except ImportError:
-        return
-
-    # Checks for OpenSSL 1.0.1
-    if ssl.OPENSSL_VERSION_NUMBER >= 0x1000100F:
-        return
-
-    try:
-        from pip._vendor.urllib3.contrib import securetransport
-    except (ImportError, OSError):
-        return
-
-    securetransport.inject_into_urllib3()
-
-
-inject_securetransport()