[NTR-cxg] mammary luminal epithelial cells

[aleixpuigb]

Preferred term label
luminal adaptive secretory precursor cell

Synonym(s) (add reference(s), please)
LASP (https://orcid.org/0000-0001-6677-8489)
luminal secretory cell (PMID:37380767)
LumSec (PMID:37380767)
Luminal Progenitor (doi10.1101/2023.04.21.537845)
LP (doi10.1101/2023.04.21.537845)
luminal progenitor cell (PMID:20346151)
ER-negative luminal alveolar progenitor (https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328)
AP (https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328)
alveolar cell (PMID:35617956)
AV (PMID:35617956)
alveolar progenitor (PMID:26390871)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EPCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit and CD61.
PMID:19648928
PMID:35617956
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
https://orcid.org/0000-0001-6677-8489

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
'luminal epithelial cell of mammary gland'

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Inherited

Your ORCID
https://orcid.org/0000-0003-4969-670X
https://orcid.org/0000-0001-6677-8489

---

Preferred term label
luminal hormone sensing cell

Synonym(s) (add reference(s), please)
LHS (https://orcid.org/0000-0001-6677-8489)
luminal hormone-responsive (PMID:37380767)
LumHR (PMID:37380767)
hormone sensing cell (doi10.1101/2023.04.21.537845)
HS (doi10.1101/2023.04.21.537845)
luminal mature cell (PMID:20346151)
ER-positive luminal hormone-sensor cell (https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328)
hormone-sensing mammary epithelial cell (PMID:26390871)
HS-MEC (PMID:26390871)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A paracrine luminal epithelial cell of the mammary gland that transduce endocrine cues to affect proliferation, architectural remodeling, and differentiation of other cells in the mammary gland. In humans, a luminal hormone sensing cell can be identified by high levels of the markers EPCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133 and Sca1.
PMID:19648928
PMID:34156490
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
PMID:26390871
https://orcid.org/0000-0001-6677-8489

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
'luminal epithelial cell of mammary gland'
'paracrine cell'

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Inherited

Comments

1. In non-pregnant mammals, LHS cells express estrogen, progesterone, androgen, and prolactin receptors. (PMID:26390871)
2. In response to progesterone, a luminal hormone sensing cell expresses TNFSF11, WNT4, and RSPO1, among other factors, which cause branching and proliferation and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. (PMID:34156490, https://orcid.org/0000-0003-4969-670X)
3. During ductal elongation, ER activity drives expression of AREG, which is necessary for proliferation of the epithelium to fill the mammary fat pad. (PMID:34156490, https://orcid.org/0000-0003-4969-670X)

Your ORCID
https://orcid.org/0000-0003-4969-670X
https://orcid.org/0000-0001-6677-8489