Addresses #2178 relabel and edit 'mammary alveolar cell' #2196
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Fixes #2178 relabel and edit 'mammary alveolar cell'
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| AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19022771") obo:IAO_0000115 obo:CL_0002325 "The milk-producing cell of the alveolar unit that emerges during pregnancy.") | ||
| AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19022771") Annotation(oboInOwl:hasDbXref "PMID:28717367") Annotation(oboInOwl:hasDbXref "PMID:35091553") Annotation(oboInOwl:hasDbXref "PMID:35377806") Annotation(oboInOwl:hasDbXref "doi:10.1177/156482659601700404") obo:IAO_0000115 obo:CL_0002325 "A glandular epithelial cell that is part of a mammary gland alveolus and differentiates from luminal adaptive secretory precursor cells during lactogenesis I. Following secretory activation during lactogenesis II, a lactocyte is involved in the biosynthesis and/or concentration of milk oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines, as well as their transport into the lumen of the lactating mammary gland.") |
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- Consider noting milk-production in the first sentence.
- "... differentiates from luminal adaptive secretory precursor cells." Consider making cells singular.
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Defer content review to SMEs already involved; otherwise, approving with comments below.
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expected to find a relationship with this cell type to 'mammary stem cell'.
From the dbxref for 'mammary stem cell':
"These stem cells have a unique capacity for self-renewal as well as for generating the three lineages that comprise the lobulo-alveolar structure of the adult gland: myoepithelial cells forming the basal layer of ducts and alveoli, ductal epithelial cells lining the lumen of ducts, and alveolar epithelial cells synthesizing milk proteins" -
A related article that may be of interest for adding additional subtypes:
https://www.science.org/doi/10.1126/sciadv.abm6865
Thank you for your comment. I will ask the SME about it, but currently it is known that these cells differentiate from luminal adaptive secretory precursor cells. LASP might be currently what 20 years ago were thought to be mammary stem cells, since they proliferate and differentiate. |
Fixes #2178 relabel and edit 'mammary alveolar cell'