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add beneficial-containing DFE #1469
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For a DFE with positive selection in humans—we could use this one from Table S6 of Zhen et al. (2021). This DFE is for nonsynonymous mutations. We inferred 1.55% of nonsynonymous mutations were positively selected in humans with a s of 0.0001124605. The remaining nonsynonymous mutations came from a DFE for negative selection (parameters for this are in Table S3). The shape parameter is 0.19 and the scale (beta) in terms of s is 0.074. |
For instance we could get it from Zhen et al in Genome Research (including Lohmueller); see citations in that paper.
https://genome.cshlp.org/content/31/1/110.abstract
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