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MERLot: A MEthod for Reconstructing Lineage tree Topologies using scRNA seq data

MERLot is a tool that can reconstruct the lineage tree topology that explains the emergence of different cell types from a progenitor population. MERLot is an R package than can reconstruct complex lineage tree topologies using coordinates for cells in a given manifold(like diffusion maps) as input.

Please follow the instructions from the installation section for preparing your system to use MERLoT.

Once you installed everything you need, please take a look at this tutorial, where we show the main characteristics of MERLoT on a real dataset.